Sr. Scientist, CMC Upstream Gene Therapy Development

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

Neurocrine Biosciencesis a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visitneurocrine.com, and follow the company onLinkedIn,XandFacebook. (*in collaboration with AbbVie)

About the Role:

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• Supports project planning efforts. Participates on cross-functional teams representing Chemical Development

• Maintains accountability for assigned deliverables for R&D and manufacturing plans for Chemical Development projects

• Independently plans and executes activities towards the goals of one or more project work streams to support Chemical Development Programs

• Ensures laboratory work is done productively and practices safe laboratory skills

• Performs process R&D and optimizes drug substance processes

• Recommends alternatives, performs research towards new methods and techniques to solve problems

• Assists with managing off-site synthesis, manufacturing activities and may interact with contractors

• May provide input for portion(s) of CMC regulatory documentation and supporting work

• May train lower-level scientists and/or team members

• Builds and enhances internal and external professional relationships

• Other duties as assigned

• BS/BA degree in Chemistry, chemical engineering, or other similar scientific fieldand 4+ years of experience in experience in pharmaceutical/process development field, including API manufacturing experience OR

• MS/MA degree in Chemistry, chemical engineering, or other similar scientific field and 3+ years of similar experience above OR

• PhD in Chemistry, chemical engineering, or other similar scientific field and 2+ years relevant industry experience; may include postdoc experience

• Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes

• Able to explain the process behind the data and implications of the results and plan next steps

• Strong knowledge of scientific principles, methods and techniques

• Strong knowledge and demonstrated ability working with a variety of laboratory equipment/tools

• Ability to work as part of a team; may train lower level scientists

• Strong communications, problem-solving, analytical thinking skills

• Detail oriented yet can see broader picture of scientific impact on team

• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency

• Ability to build and manage internal and external working relationships

• Strong understanding of gene therapy and/or antibody development and manufacture

• A well-developed understanding of biologics (upstream and/or downstream) as well as current techniques and literature

• Strong laboratory and productivity skills

• Drug substance manufacturing experience both internal and with external partners

• Good understanding of cGMP requirements and regulatory aspects of biologics

• Demonstration of cross-functional understanding related to drug development

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Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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